Thus, lowaffinity yet broadspectrum bromodomain inhibition by nmp mediates biologically potent, cereblonindependent immunomodulation and at higher doses targets malignant cells directly via bet antagonism. Nmethylpyrrolidone proposition 65 warnings website. Company is located in hefei city chemical industry base of circular economy park in anhui province, is set product development, production, sales as one integrated enterprise with foreign trade import and export operation rights. Nmethylpyrrolidone nmp is a solvent used in a variety of industries and applications, such as paint and coating removal, petrochemical processing, engineering plastics coatings, agricultural chemicals, electronic cleaning and industrialdomestic cleaning. Reproductive toxicants 2,4d butyric acid, mdinitrobenzene, hydramethylnon and nmethylpyrrolidone notice of revised time for the public hearing for proposed amendments to title 22, california code of regulations, section 12805, specific regulatory levels. Assessing the oxidative degradation of nmethylpyrrolidone nmp. Parchem is open and ready to supply materials 18002823982 read more. Occasionally new compounds in patchouli oil are reported 159, 161 or the structure of a known compound corrected. This website is maintained by the united states manufacturers of nmethylpyrrolidone nmp, and is intended to provide information relating to nmp. Epa600r98067 june 1998 environmental profile for nmethylpyrrolidone by research triangle institute research triangle park, nc 277092194 and science applications international corporation reston, va20190 contract no. Nmp is widely used in the petrochemical industry, and in the manufacturing of various compounds, including pigments, cosmetics, insecticides, herbicides, and fungicides. Solvents for ultraviolet spectrophotometry references.
The data represent a small sub list of all available data in the dortmund data bank. It is a nalkylpyrrolidine, a lactam and a member of pyrrolidin2ones. Consumers with specific questions regarding a business decision to provide a warning should contact the business. This chemical inventory is oshas premier onestop shop for occupational chemical information. Nmethylpyrrolidone reference spectrum european pharmacopoeia ep. Stone sustainable technology division national risk management research laboratory cincinnati, oh. Flammable liquids, category 4 skin irritation, category 2 eye irritation, category 2a reproductive toxicity, category 1b. Nmethylpyrrolidone nmp harms the developing fetus when tested in pregnant animals. Nmethylpyrrolidone 1 july 2011 nmethylpyrrolidone 1methyl2pyrrolidinone nmethylpyrrolidone is an industrial solvent which is widely used in industrial applications, such as petroleum refining, the formulation of pesticides, and as an agent in some veterinary pharmaceutical products. Although manufacturers say nmp is safe to use when handled properly, these health concerns have opened opportunities for alternative solvents and processes that make do without nmp. If you have any questions, comments, or concerns about the content of this page, please submit this form. Pdf photocatalytic degradation of nmethyl2pyrrolidone. Its good solvency properties have led to nmps use to dissolve a wide range of polymers.
Material safety data sheet imperial college london. It is an excellent solvent for many coatings, including polyurethanes, printing inks, epoxy resins, polyamidimidebased wire enamels, and waterbased coatings. View detailed import data, price, monthly trends, major importing countries, major ports of n methylpyrrolidone. The structure of the compound was established by spectroscopic analysis uv, 1h and c nmr and elucidated with the aid of cosy, hmqc, and hmbc experiments. A uvvisible absorption spectra of nmp showing absorbance. Import data and price of n methylpyrrolidone zauba. Many factors can contribute to seal performance in actual field conditions. Many plastics, including polystyrene, polyesters, and polyvinyl chloride are soluble.
It is miscible with water and with most common organic solvents. Interaction of nmethylpyrrolidone with doped polyaniline. The level of expertise involved in uv is basic to advanced. An overview of forensic drug testing methods and their. Prevention of uv radiationinduced cutaneous photoaging in. It is toxic to the reproductive system of male and female test animals. Osha no component of this product present at levels greater. Nmethyl2pyrrolidone appears as a clear colorless liquid with a fishlike odor. Technical data elastomer compatibility lyondellbasell.
Osha occupational chemical database occupational safety. The health risks associated with a chemical depend on its hazard its potential to cause health effects and the amount of substance to which a person is exposed. Uvvis spectra of nmp sonicated for 5, 30 and 120 min showed significant absorbance at around 350 nm. It compiles information from several government agencies and organizations. Technical data nmethyl2pyrrolidone nmpel electronic grade nmethyl2pyrrolidone nmp is a powerful, aprotic solvent with high solvency, and low volatility. The technique may be easily taught to someone with little to know theoretical knowledge of the technique, although interpretation. The analysis of nmethylpyrrolidone nmp for amines by ic is used to determine that nmp is free from contamination of amines. Technical data elastomer compatibility thf, gbl, nmp and bdo introduction the data provided here addresses the ability of the elastomerseal material to resist the contacting fluid. The sample is injected on a ion chromatograph capable of detecting and quantifying amines in nmp.
Vapor pressure of nmethyl2pyrrolidone from dortmund. Paint makers and other solvent users regarded nmp as something of a wonder. Nmethylpyrrolidin2one is a member of the class of pyrrolidine2ones that is pyrrolidin2one in which the hydrogen attached to the nitrogen is replaced by a methyl group. Prevention of uv radiationinduced cutaneous photoaging in mice by topical administration of patchouli oil. Sonochemical degradation of nmethylpyrrolidone and its influence. Nmethylpyrrolidone nmp is a watermiscible organic solvent. The experimental data shown in these pages are freely available and have been published already in the ddb explorer edition. Epa will incorporate comments and feedback in issuing the final risk evaluation. For more data or any further information please search the ddb or contact ddbst component. Search results for nmethylpyrrolidone at sigmaaldrich. The sample is injected on a gas chromatograph equipped with a flame ionization detector capable of detecting and quantifying contaminants in nmp. Specifically, it is used as a solvent for surface treatment of. The drug vehicle and solvent nmethylpyrrolidone is an immunomodulator and antimyeloma compound.
Photocatalytic degradation of nmethyl2pyrrolidone in aqueous solutions using light sources of uva, uvc and uvled. Individual compounds were identified through comparison of substance mass spectrum with the nist database. Nmp and nep are not presently a concern for the environment or human health at current levels of exposure. Nmp is desorbed from the solid adsorbent and extracted from the absorption solution by an organic solvent. The absorbance likely corresponds to scattering from the. The reproductive effects of nmp in humans have not been studied. Solvents for ultraviolet spectrophotometry this table lists some solvents commonly used for sample preparation for ultraviolet spectrophotometry. Additionally, uv spectrum can vary depending upon the ph of the sample solution, and it is possible for chemical composition to change during the analysis. Clathria frondifera, nmethylpyrrolidone, nmr, sponge since last two decades, research into marine natural products has expanded rapidly. Our specialty is solving sealing problems for original equipment manufacturers. Uv vis and ion chromatography ic analyses were employed to obtain the. Chemical identification and physical properties exposure limits sampling information.
Articles of nmethylpyrrolidone are included as well. The analysis of nmethylpyrrolidone nmp for purity assay by gcfid is used to determine nmp purity to the nearest 0. Once touted as benign, the solvent nmethyl2pyrrolidone nmp is under scrutiny because of concerns over its potential health effects. Nmp has a good solvency for a wide range of organic and inorganic compounds and it is miscible with water at all temperatures and has a high chemical and thermal stability. It had been agreed by the members of the expert working group ewg that the permissible daily. There is no warranty of accuracy or completeness of any information contained herein. Structure, properties, spectra, suppliers and links for. Nmethyl2pyrrolidone nmp is an organic compound consisting of a 5membered lactam. Dr munir ahmad nmp 2 protective equipment eyes wear safety glasses. Pde for nmethylpyrrolidone nmp the ich q3c guidance reached step 5 in december of 1997. Safety data sheet nmethylpyrrolidone 000000011705 page 2 14 version 1.
Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that echa is. Skin wear protective work clothing and impervious gloves. This colorless, high boiling, high flash point and low vapor pressure liquid carries a mild amine like odor. Based on the animal tests, you should treat nmp as a potential human reproductive hazard. Fluid first letter n compatibility chart vs various. Nmethyl2pyrrolidone cleans heavy oil and carbon deposits from engine parts. Nmp hplc grade was used as received and anhydrous nmp was degassed by freezethaw in liquid nitrogen x 5 before use. A uvvisible absorption spectra of nmp showing absorbance below 450 nm increasing with the age of the nmp, from nmp1 to nmp9. Methylpyrrolidone, nmp, is a high boiling, polar aprotic, low viscosity liquid. Welcome to the nmethylpyrrolidone producers group, inc. Material safety data sheet this product is classified as hazardous based on directive 67548eec as amended or directive 199945ec of the commission of the european communities printing date. Nmethylpyrrolidone nmp testing for purity assay by gcfid. Storage in an airtight container, protected from light. As the vcd spectrum can be theoretically calculated, it allows the.
Download scientific diagram a uvvisible absorption spectra of nmp showing absorbance below 450 nm increasing with the age of the nmp, from nmp1 to. The drug vehicle and solvent nmethylpyrrolidone is an. Predicted data is generated using the us environmental protection agencys episuite. Als columbia does not sell chemicals, such as nmethylpyrrolidone 872504, but offers analytical lab testing to determine the presence of various elements and chemical compounds. It is a colorless liquid, although impure samples can appear yellow. Nmethylpyrrolidone n methylpyrrolidonenmp nmp health hazard advisory nmethylpyrrolidone nmp harms the developing fetus when tested in pregnant animals. It is used in the petrochemical and plastics industries as a. It also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
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